Chromatography Research Today is a free monthly online journal that collates and summarizes the latest research about Chromatography, including details on column chromatography, gas chromatography (gc), liquid chromatograpy, hplc.

Determination of trace level chemical warfare agents in water and slurry samples using hollow fibre-protected liquid-phase microextraction followed by gas chromatography-mass spectrometry.

Lee HS, Basheer C, Lee HK

DSO National Laboratories, Singapore.

A simple and solvent-minimised sample preparation technique based on hollow fibre-protected liquid-phase microextraction was investigated for the gas chromatography/mass spectrometric analysis of chemical warfare agents in water and slurry samples. The chemical warfare agents included four nerve agents and a blister agent. Parameters such as extraction solvent, salt concentration, stirring speed and extraction time were optimised using spiked deionised water samples. The technique provided a linear range of two orders of magnitude, good repeatability (RSDs < 10%, n = 6), good linearity (r2 >or= 0.995) and limits of detection (LODs) in the range of 0.02-0.09 microg l(-1) (S/N = 3) under full scan mode. The optimised technique was also applied to more complex slurry samples and similar precision (RSD < 15%, n = 3) and limits of detection (0.02-0.2 microgl(-1), S/N = 3) were obtained.

Published 1 September 2006 in J Chromatogr A, 1124(1): 91-6.
Full-text of this article is available online (may require subscription).

© 2005-2008 Chromatography Research Today. All Rights Reserved.